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But the most striking finding was the effect on relapse frequency

The clearance of these vitamins is primarily renal, as they are water-soluble and excreted through the urine

Skorokhod O, Schwarzer E, Ceretto M, Arese P (2007) Malarial pigment haemozoin, IFN-gamma, TNF-alpha, IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno-purified human monocytes

Metabolic rate (influenced by thyroid function, body composition, and physical activity) also modulates drug clearance, with higher metabolic rates potentially shortening half life and lower rates extending it

"[Associations between insulin resistance and three B-vitamins in European adolescents: the HELENA study]"