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Key quality indicators to look for include third-party testing with certificates of analysis (COA) showing purity above 98%, proper lyophilization (the powder should be a clean, white cake, not a yellow or clumpy mass), appropriate packaging (amber vials to protect from light degradation), and clear labeling including peptide identity, mass, lot number, and expiration date

Consultation Initial assessment starts with a focused clinical review to judge peptide suitability

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Dillon et al., in a phase I clinical trial, evaluated a vaccine containing nine breast-cancer-associated peptides (MHC I restricted) from MAGE-A1, 3A3, and AA10 proteins, CEA, NY-ESO-1, and HER2/neu along with a TLR3 agonist, Poly-ICLC, and an adjuvant derived from tetanus toxin