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J Dermatol Treat

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Abstract The metabolism of tumor cells exerts a great influence on the tumor microenvironment (TME) of solid tumors and antitumor immune responses

In contrast, during molecular dynamics simulations, the spatial orientation of Arbutin in the Arbutin_b conformation shows noticeable changes compared to its docked structure, which may be attributed to the limited space within the binuclear copper active site that constrains the positioning of the pyranosyl glucose moiety (Fig