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In animal studies spanning three decades, no lethal dose has been identified

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Development and characterization of a melphalan-resistant human multiple myeloma cell line

To confirm the phenotype changes were driven by OGDHc inhibition, we also treated cells with DM-2OG, mimicking impaired 2-OG metabolism by the OGDHc, and found that, similarly to ML226, DM-2OG increased the CCR7 high CD45RO high population, with a corresponding decrease in the CCR7 low CD45RO high population (Fig

A central role for free heme in the pathogenesis of severe sepsis