It is produced naturally by the liver and involved in many processes in the body, mainly detoxification but also plays a role in tissue building and repair, making chemicals and proteins, and for immune system support
Maybe it was mixed with other actives and that caused the irritation
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The best way to maximise these stores (if you are supplementing for the first time) is to take creatine (about 5g, or 0.3g/kg body weight) four times a day for five to seven days