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England et al., 2025)

Niacin (NA), nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN) followed in effectiveness

2018;8(6):a029751

Inspired by intracellular multi-enzyme cascade reactions, researchers initially attempted to construct artificial cascade systems by encapsulating natural enzymes within porous synthetic materials, including metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and hydrogen-bonded organic frameworks (HOFs) (Lykourinou et al., 2011