As we begin to better understand the role of the gut-derived metabolites on the system, it will be interesting to incorporate and exploit these interactions for the purpose of therapeutics to either restore or protect against BBB breakdown
In real-world settings, efficacy may differ due to patients ability to remember to take the medication, administer it properly, tolerate its side effects, and more
2** Safety data generated in the REDEFINE 1 and 2 trials was comparable with the GLP-1 RA class
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Xia T, Duan W, Zhang Z, Li S, Zhao Y, Geng B, Zheng Y, Yu J, Wang M (2021) Polyphenol-rich vinegar extract regulates intestinal microbiota and immunity and prevents alcohol-induced inflammation in mice