Although the change from eumelanin (dark pigment) to pheomelanin (lighter pigment) is more closely associated with internal glutathione, topical glutathione nevertheless supports lighter pigment pathways by reducing oxidative triggers and improving cellular repair
Such modifications can result in loss of enzymatic activity, altered cellular signaling, and degradation of structural proteins, contributing to cellular dysfunction and death [36, 37]
Glutathione plays a key role in stimulating collagen synthesis by reducing free radicals that damage collagen-producing cells
N., Aldous, C., Kruger, H
Figure 4 in Section 5) but can also directly scavenge several ROS, including peroxynitrite, HOCl, and OH (Tambyraja et al., 2007)