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A zebrafish study demonstrated that AGAT and GAMT were broadly expressed in multiple tissues (central nervous system, liver, and pancreas) in the same pattern as the homologous genes expressed in mammal tissues [30]

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Activation of nuclear factor-B (NF-B) induces transcription of target genes that primarily encode survival proteins (e.g., cellular FLICE-like inhibitory protein and inhibitor of apoptosis proteins) via formation of the complex I signalosome after binding to TNF receptor-1