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Alcoholic liver disease: Chronic alcohol consumption severely depletes hepatic glutathione through multiple mechanisms: increased ROS production during ethanol metabolism, reduced cysteine availability, and impaired mitochondrial glutathione transport

Secondary plots of the k obs values from single exponential fits of the first phase and double exponential fits of the second phase against the GSSG concentration yielded a linear and hyperbolic correlation for the first and second phase, respectively (Fig

Journal of the American Chemical Society 137 , 21282136, (2015)

Arq Bras Cardiol

Collectively, these investigations suggested the plausibility of modulating the rate of drug release as well as specifically targeting different GSTs by modifying the sulfonamide moiety 128