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After 72 hours of treatment, CYP3A4 activity was assessed using the P450-Glo CYP3A4 (Luciferin-PFBE) Cell-Based/Biochemical Assay (Promega) according to manufacturer instructions

Larger trials conducted on a broader population would be valuable in confirming these findings and establishing GSH as a neuroprotective agent in clinical practice

PI3K/Akt/mTOR signaling pathway and its importance in cancer PI3K/Akt and mammalian target of rapamycin (mTOR

The depletion of glutathione leads to the (i) release of inflammatory cytokines, (ii) the formation of free radicals, and (iii) the inhibition of some cell functions, all of which have been known to cause many chronic degenerative diseases and functional loss with ageing