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A key component of the cellular antioxidant system, System Xc is a type of amino acid anti-transporter that is substantially dispersed in a lipid bilayer and is a very selective cystine uptake system (Liu et al., 2021)

Furthermore, H&E staining showed that compared to the aorta of normal aging mice, the aorta of mice treated with FOXO4-DRI was thinner, and the PWV value was lower in the ultrasound detection results, which means that the mice treated with FOXO4-DRI had better vascular elasticity and better vascular function than normal aging mice (Figures 1D,E)

Additionally, crosslinking density, polymer hydrophobicity, and nanoparticle size distribution are often overlooked variables that critically affect responsiveness and cytotoxicity

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IGF-1 LR3 functions as a potent, long-acting agonist of the IGF-1 Receptor (IGF-1R) , activating key intracellular signaling pathways, primarily the PI3K Akt and MAPK pathways