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Upregulation of sense gene via NAT degradation While the previously mentioned mechanisms function to upregulate the sense gene by directly acting upon the sense gene mRNA transcript, one limitation lies in the fact that uORFs only exist in approximately 50% of mammalian mRNA and within this 50%, not all are inhibitory [106, 107]

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With these parameter values, model simulations are performed to collect information on an outcome of interest, which can be the model output or another outcome, and finally a PRCC is calculated for each input factor