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Sikiric P, Mikus D, Seiwerth S, et al

Preclinical studies demonstrate that DSIP can alter pain threshold responses, with observed effects that are not reversed by opioid receptor antagonists such as naloxone, suggesting involvement of non-opioid or indirect neuromodulatory pathways [7]

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10-13,29 IBTs have also been associated with sarcopenia or loss of lean muscle mass, particularly in older adults, frail individuals, and those with chronic comorbid conditions