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8 Functions of GSH in redox buffering, detoxification, and drug resistance Glutathione (GSH) is the principal intracellular redox buffer that preserves cellular homeostasis through detoxification of ROS and regeneration of antioxidant capability via GR-catalyzed recycling of its oxidized form (GSSG)

Although it is tempting to speculate that it is endogenous IGF-1 that is critical for NK cell cytotoxicity, we cannot rule out the possibility that there is some contribution of exogenous IGF-1 from circumstances in vivo

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