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doi: 10.1016/j.ahj.2011.06.012

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By combining GLP-1 receptor agonism with glucagon receptor activation, it tackles both sides of the weight-loss equation: Less intake through appetite suppression and delayed gastric emptying More burn through increased energy expenditure and hepatic fat metabolism Early Phase 2 data showed double-digit weight loss (up to ~19%), improvements in glycemic control, and reductions in liver fat and fibrosis markers, suggesting its role may extend well beyond weight management into MASH treatment

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