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Since ApoE, A and Tau each play their own homeostatic role yet also alternatively function as antimicrobials, it is no surprise that they all have a high degree of mutual interaction

Therefore, binding of the nanobody does not completely fix gB in a single position as in the case of the stabilizing mutations, as areas such as the transmembrane region remain flexible, but rather seems to prevent the principal conformational changes required for fusion

doi: 10.1007/s00210-019-01678-3 60