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Because B12 is water-soluble, your body uses what it needs and passes most of the excess, and there is no established upper intake limit because harmful effects from high intake have not been well documented

If your vial accidentally froze (stored too close to the freezer compartment or in a refrigerator set below 0C), discard it immediately there is no salvage method and no at-home test to confirm remaining activity

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In particular, nitric oxide (NO) regulates vascular tone and blood flow by promoting the relaxation of all types of blood vessels, including arteries a phenomenon called vasodilation