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[24] In one study, fullthickness wounds of 6 millimeters in diameter were created in an ischemic skin flap on the backs of rats, and for 13 days the wound sites were then treated daily with topical GHK-Cu or topical hydroxypropyl methylcellulose vehicle, or given no treatment

A Cleveland Clinic review notes that one case report described symptoms only after a cumulative 15,000 mcg (15 mg) of injected B12 over several weeks

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Combined with biomarker assessment of oxidative stress burden, this information should be interpreted with a qualified healthcare provider to guide personalized supplementation strategy

In case there is any post-treatment discomfort, consulting the provider is advised