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Given the striking decrease of 55% of cells entering the S-phase of the cell cycle upon treatment with 2 ng/mL and 10 ng/mL of BPC 157 and decreased ERK phosphorylation, it was suggested that BPC 157 acts as an antimitogenic agent by preventing ERK phosphorylation and the propagation of the mitogenic signal via the MAPK signaling cascade, triggered by VEGF [95]

A large patient-level meta-analysis showed that estimated glomerular filtration rate (eGFR) decline and albuminuria are both associated with increased risk of adverse CV and renal events in the general population 78

As a consequence of this article, we included in our clinical reports a recommendation to check B12 levels prior to the next injection to clarify status

The IC values for each tested molecule are presented in Table 6