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Although the value of Vd does not confirm penetration of a drug into specific tissues, in general the higher the value of the Vd, the more likely it is that the drug will reach sequestered sites such as the brain and cerebrospinal fluid, the prostate and other sex organs, the eye, and the mammary gland

For FOXO4-DRI, this modification is essential because it allows the therapeutic peptide to persist long enough in vivo to reach and enter senescent cells

doi:10.1016/j.jaci.2014.11.003 4

You should address any concerns about premature grays or hair loss with a doctor.