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110 However, in one large placebo-controlled trial in 2,370 men with infertility, treatment with 30 mg of elemental zinc plus 5 mg (8,500 mcg DFE) folic acid daily for six months increased DNA fragmentation and did not lead to improvements in sperm parameters or pregnancy rate

Data analyses were carried out in part in the High Performance Computing Center of University of Tartu

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Answer: Patients often describe subtle changes in the first one to two weeks, more noticeable improvement between weeks two and six, and the most meaningful change by the end of an eight-to-twelve-week protocol