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Triacetin was, however, assessed to have low toxicity to aquatic invertebrate Daphnia magna [98] and therefore, might not play a major role in the toxicity we observed on C

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However, PROTACs still require optimization for PAH application, such as improving pulmonary tissue targeting to reduce systemic toxicity and verifying pulmonary vascular safety in preclinical models (Kelm et al

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