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In this study, we systematically determined the IC50 values of glioblastoma cell lines for metformin and performed fitting calculations (Table S3)

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These mechanisms raise a theoretical concern: could supratherapeutic doses accelerate unwanted vascular growth or disrupt dopamine signaling enough to produce neuropsychiatric symptoms

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To overcome these burdens, modern technology attempted to replace conventional treatments by designing smart hybrid nanosystems that can deliver drugs to localized sites to prevent infection by overcoming barriers imposed by biofilms and regulating complex wound microenvironment, thus promoting tissue regeneration in the wounded site