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The heterogeneity of ARDS affects the efficacy of various treatments, including drug therapy, respiratory management, ECMO (275)

The half-life sits around 5 days, which is why weekly dosing works

By mitigating oxidative damage in animals exposed to captivity stress or environmental toxins, antioxidants have been used to improve breeding success rates, exemplified by their use in endangered amphibian programs

l-carnitine reduces the adverse effects of ROS and up-regulates the expression of implantation related genes in in vitro developed mouse embryos

Later, the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus reinforced that probiotic should be reserved for strains that are taxonomically defined, safe for their intended use, supported by at least one positive human clinical trial, and present alive at an efficacious dose throughout shelf life (521, 522)