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The most common melanomas in non-White population arise from epithelium-asssociated melanocytes on acral skin (palms, soles, nail apparatus) or mucous membranes and are characterized by an early onset of major chromoscomal rearrangements, such as chromotripsis, with gene copy number changes, including multiple high-level amplifications (8)

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How They Work: Mechanism Explained Glutathione Mechanism Glutathione works at a cellular level by: Neutralising free radicals that cause oxidative damage Supporting liver detoxification Regulating melanin production by shifting it from darker eumelanin to lighter pheomelanin Regenerating other antioxidants like Vitamin C and Vitamin E Because it works internally, glutathione improves overall skin quality, not just pigmentation