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Mechanistic studies have revealed that the application of Gln metabolic inhibitors or the knockdown of the transmembrane protein SLC1A5 can inhibit the YAP1/TEAD signaling cascade, which is known to promote mesothelioma invasion and metastasis ( 2.1.2 Promoting drug resistance in tumor cells The dysregulation of Gln metabolism is closely associated with the development of tumor resistance (24)

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The nasal delivery method allows for the medication to be quickly and effectively absorbed into the bloodstream, ensuring it reaches the affected areas promptly

thaliana (Machens et al., GST promoters (Figure 3)