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TUNEL-positive cells and 4-HNE accumulation were observed within TLS in both sulfasalazine-treated and vehicle-treated mice, while cleaved caspase-3, an apoptosis marker, was not evident in either group (Figure 5C)

The exploration of these sulfur-containing amino acids opens avenues for understanding pathophysiological mechanisms and suggests potential targets for therapeutic interventions

doi: 10.1177/0271678X20967459

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Most promisingly, we could successfully soak in and solve crystal structures with the NMR hit 27 and several of its analogues to fully characterise the binding modes within this fragment hit series