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I personally have two copies of the MTHFR mutation and am alive and well (with some interventions), while others I have seen have just one copy of a mutated gene, and a lot of symptoms

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A patient with a serious non-healing musculoskeletal injury, conventional options exhausted, full informed consent, ideally inside a registered investigational protocol with structured safety monitoring

At 20 mcg/day the raw math reaches ~50 days, exceeding the 30-day reconstituted window reconstitute the vial in halves (0.5 mg each) for slower protocols

Metabolic regulation of homologous recombination repair by MRE11 lactylation