In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 100%, or higher than 100%, compared to an otic formulation that is not a controlled-release otic formulation
Discontinuing an evidence-based IBD therapy like a biologic in favor of an unregulated peptide carries an exceptionally high risk of inducing a severe, uncontrolled disease flare that could lead to hospitalization or surgery
A big factor in healing joint, tendon, and ligament damage is reducing pain, so that you can increase activity and range of motion which, in and of itself, can be healing
For PIH from acne, glutathione accelerates fading by inhibiting tyrosinase activity in healing skin patients typically see 4050% reduction in dark spot intensity over 1012 weeks
Immunofluorescence analysis reveals that GHK-Cu treatment leads to upregulated CD31 expression in scalp tissue, indicating enhanced angiogenesis
