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Aberrant DNA methylation patterns have been identified in patients with HT, leading to gene silencing and altered expression of genes regulating the immune response, along with hypermethylation of specific CpG sites

Gasthuys, E

doi: 10.1073/pnas.1316569111 57 ZurekG.KarstU

Or I guess with Ozempic, that's exactly what happened

[11] [4] Preclinical studies have suggested that combining amylin receptor agonism with GLP-1based therapies produces greater reductions in food intake and body weight than either approach in isolation, and early clinical data from the CagriSema programme (cagrilintide combined with semaglutide) has provided some supporting evidence in humans