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Description

Regarding metabotropic glutamate receptors, different subunits of metabotropic groups I (mGluR5), II (mGluR2 and 3), and III (mGluR4, 6, and 8, but not mGluR7) are expressed by microglia and regulate microglial transformation into neuroprotective ( via group III mGluRs) or neurotoxic ( via group II mGluRs) phenotypes (Pocock and Kettenmann, 2007)

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