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Environmental and metabolic factors like food, gut microbiota, and insulin resistance affect epigenetic changes, such as DNA methylation, histone modifications, and non-coding RNAs[60]
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Perspective: Physiologic Importance of Short-Chain Fatty Acids from Nondigestible Carbohydrate Fermentation
Effective clinical management of PASC is contingent upon the following critical evaluation of dysbiosis: (i) the duration of gut dysbiosis after COVID recovery, (ii) the link between gut dysbiosis and long-term persistent symptoms, and (iii) the possible adverse health effects from enriched or depleted specific gut microflora on COVID-19 recovered individuals 254
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