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This is what they said specifically about the tobacco particle range: Accurate measurement of cigarette smoke particle size distribution is important for estimation of lung deposition

No HPBA formation was observed with either CYP2A6- or CYP2B6-overexpressing microsomes when nicotine was used as substrate in the present studies, a pattern consistent with that observed in previous studies demonstrating a lack of HPBA formation activity by CYP2A6 with nicotine as the substrate

Moving on from disposables

One of the standout advantages of whole leaf tobacco is the cleanliness and quality control you get with every leaf