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A multi-target approach is being explored in place of traditional single-target drugs

Their elevated activity shows decreased corneocyte adhesion and desquamation [16]

This suggests the significance of the hydrophobic nature of the interface in the FOXO4 FHD and p53 TAD interaction

However, the most important caveat applies here: human pharmacokinetic data confirming systemic oral bioavailability does not exist in the peer-reviewed literature as of 2025

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