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Some early studies in animals have shown a potential risk to foetal development, which is why current advice is to avoid use in pregnancy and stop treatment well in advance of trying to conceive

Study limitations include small sample sizes, short durations, and lack of standardized fertility endpoints

Similarly, polyunsaturated fatty acids are susceptible to oxidation

DG received speaking honoraria from Pfizer and Bristol Meyers Squibb outside the submitted work and participated in this research project funded by Bayer with funds paid to the institution where he is employed

10.1016/j.fertnstert.2014.02.002 44 RasmussenJ