Although peak inflammatory cytokine production (e.g., IL-1) may stem from localized MAPK/ERK dysregulation rather than direct endotoxin influx 174 , the cumulative impact of gutliver axis dysfunction in destabilizing cellular homeostasis remains an indispensable driver of the systemic pathogenesis of bovine laminitis
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18 Patients with other autoimmune diseases, CVD, diabetes mellitus, endocrine disorders, acute and chronic pancreatic disorders, malignancy, pregnancy, breastfeeding, and those using antihyperlipidemic drugs were excluded from the study