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Different from full-length GH (experimental): Research suggests minimal effect on IGF-1 and limited activation of classical growth hormone receptor signaling compared with intact GH

A recent study further demonstrated that proline catabolism via PRODH supports 3D growth of breast cancer cells, with elevated PRODH expression and proline oxidation in metastatic lesions compared with primary tumors, thereby promoting metastatic colonization and identifying PRODH as a potential target for metastasis suppression 64

Thyroid hormone and not growth hormone is the principle regulator of mammalian mitochondrial biogenesis

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Mol Psychiatry 25 , 19201925 (2020)