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How the rules changed in three years The regulatory saga runs from the first restriction in 2023 to a review still in progress

J Pharmacol Exp Ther 1973;187:185-94

Environmental factors such as heavy metal toxicity [1012], sub-clinical viral infections [13] and gastro-intestinal pathology [14, 15], as well as endogenous toxins produced by metabolic processes [16], hormones (reviewed in [17]) and gastro-intestinal bacteria [18, 19] have also been suggested as playing a role in the aetiology of the disorder, although none of these have been thoroughly investigated

In addition to these hallmark features, AD is associated with oxidative stress, neuroinflammation, synaptic dysfunction, and neuronal loss

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