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Hepatology (Baltimore, Md.), 65 (1), 363

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Two agents deserve serious attention here: Pentosan Polysulfate Sodium (PPS) - inhibits NF-B, suppresses TNF- and IL-6 simultaneously, inhibits cartilage-degrading enzymes, and uniquely *strengthens* cartilage matrix through increased structural cross-linking

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Its natural purpose is to protect the gut lining from the harsh acids of the stomach and to rapidly heal any ulcers or lesions

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this however is time consuming, expensive and separated from real-world experience

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