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7 Kupffer cell activation is responsible for early ethanol-induced liver injury, common in chronic alcoholics

Chasan-Taber L, Willett WC, Seddon JM, et al

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Yang et al., 2002

Such vascular responses are particularly relevant in experimental models of ischemia, where enhanced circulation contributes to tissue preservation and recovery.(22) In addition to its effects on vascular growth, it has been associated with regulation of vascular tone through interactions with nitric oxidedependent signaling mechanisms