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A study performed in primary cultures of OFs from GO patients and control subjects demonstrated that quercetin exerts an inhibitory effect on fibroblasts proliferation and HA release, with no difference between GO and control fibroblasts ( in vivo studies are needed to confirm this hypothesis, also considering that quercetin seems to act through necrosis, which may worsen autoimmunity against orbital antigens due to antigen exposure to the immune system

Qian et al., 2020)

The use of human ESCs was approved by the Ministry of Education Culture, Sports, Science and Technology of Japan (MEXT)

Dilution of the acetylcysteine solution (see Preparation of Acetylcysteine solution for Oral Administration) minimizes the propensity of oral acetylcysteine solution to aggravate vomiting

Oral glutathione has poor bioavailability