5.4 Gaps in current knowledge and future directions While genomic plasticity contributes to resistance, the precise evolutionary trajectory of resistant Leishmania strains under drug pressure remains unclear, necessitating longitudinal studies to track genomic changes in response to treatment (Santi and Murta, 2022)
As the upstream RLuc reporter is translated by cap-dependent scanning 58 , which is reported to be enhanced in YBX1 deficiency 59 , to compare the translational efficiency of the PRKAA1 5UTR in shCtrl and shGDH1 or shYBX1 cells, the FLuc activity of the empty reporter group was used for normalization, as previously described 38
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And with all of that said, the numbers can speak for themselves
