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To confirm that interface IV is essential for c-MET activation, we introduced Y673A mutation into HGF to disrupt this interface, and showed that HGF Y673 mutant has a great deficiency in binding to c-MET as well as promoting c-MET activation (Fig

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4.1.2 Inhibition of melanin synthesis by mediating inflammatory reaction Inflammation can also contribute to hyperpigmentation (Hossain et al., 2021)

At the same time, aging also means declining glutathione synthesis, which offsets the negative impact of reactive oxygen species on the bodys cell health and functions

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