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10.1093/annonc/mdt194 2 BatesD.EastmanA

Lee et al

(2023) 35:e2301779

Response rate according to the indications Consistent effectiveness under multiple conditions Key observation: The effects of DSIP persisted for several days after treatment, suggesting that it "reprograms" natural sleep patterns rather than providing temporary relief

While the NIH does not specify a tolerable upper intake level for vitamin B12, a study published in the JAMA Network Open found that high intakes of vitamin B12, such as from daily supplementation of 25 micrograms or higher, increased the risk of bone fracture [3] [4]