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Five years after starting her treatment, an 89-year-old woman developed signs of malaise, collapse, and vomiting an hour after a Neo-Cytamen shot (hydroxy B12)

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(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field