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doi: 10.1210/jc.2003-030630

Glycocalyx degradation usually begins in the SIRS stage, when proinflammatory factors (TNF-, IL-1) activate endothelial cells and directly destroy the components of the glycocalyx (such as HS, HA) by activating MMPs [23]

The urodynamic characteristics and prognostic factors of patients with interstitial cystitis/bladder pain syndrome

Severe SARS-CoV-2 infection with high cytokine levels causes T-cell exhaustion characterized by high levels of programmed cell death protein 1 and low numbers of CD4 + and CD8 + cells (Diao et al., 2020

Additionally, while FOXO4-DRI has been shown to limit chemotoxicity in certain contexts, its overall safety profile in humans requires further research to fully understand all potential side effects