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Sufficient recovery time between training sessions

In short: the efficacy signal is genuinely strong and comes from real randomized trials, but Retatrutide remains investigational

Researchers have not identified a lethal dose even at concentrations far exceeding therapeutic ranges

Furthermore, decreased levels of phosphorylated pP70S6K, a substrate of mTOR, can regulate cell proliferation, cell survival and other aspects of cellular metabolism 28

Theoretical concerns include angiogenesis-related risk in patients with current or prior cancer, and effects on nitric oxide signaling that could matter for blood pressure