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In depression, this might not be due solely to the effects of nicotine, as it has been shown that tobacco smoke contains substances with antidepressant effects (monoamine oxidases or MAO), but again some small studies have indicated a possible positive effect of nicotine treatment (6)

In countries where smoking prevalence has decreased, a corresponding decline in lung cancer incidence has been observed ( Despite these achievements, new alternatives to traditional tobacco have emerged, including vaping devices, nicotine replacement products (such as gums and patches), heated tobacco products (HTPs), and electronic cigarettes (e-cigarettes), with or without nicotine ( Since their introduction, e-cigarettes have evolved rapidly in both design and technology, from early cig-a-like models resembling traditional cigarettes to vape pens, pod systems, and heat-not-burn (HnB) devices ( Although initially marketed as a harm-reduction tool, mounting evidence indicates that e-cigarettes pose significant health risks, especially for children and adolescents

Oral cancersof the mouth, tongue, throat, and esophagusare strongly associated with pipe and cigar smoking, even without inhalation

The studys authors recommend further research on quality control, proper labeling, and the negative health effects of nicotine