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Tissue injury disorders present grievous clinical problems and are likely to increase since they are generally associated with the prevailing diseases such as diabetes, hypertension and obesity

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In terms of systemic infection and prognosis, although the polymorphism of Dectin-1/CARD9 is not consistently associated with the susceptibility to Candida bloodstream infection, the responses of the heterozygous Y238X carriers to cytokines in vitro are weakened, which may affect the inflammatory regulation and prognosis of severe infections (Rosentul et al., 2011)

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